πŸŽ—οΈ Cardio-Oncology Wizard Echo-Wizard.com

Enter the baseline scan first, then each follow-up. The latest row is compared with baseline (ESC 2022 echo criteria) and with the previous scan.

Scans

Date2D EF %Contrast EF %3D EF %GLS %TAPSE mmSβ€² cm/sFAC %

LVEF now

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Ξ” LVEF vs baseline

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percentage points

Relative Ξ” GLS

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vs baseline

Echo verdict

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LV trend

Pink: 2D EF, with triangles where contrast EF was used; purple: 3D EF (left axis) with 50% and 40% thresholds. Blue: GLS magnitude (right axis); the dotted blue line marks a 15% relative fall from the baseline GLS.

RV trend

TAPSE (mm) and FAC (%) on the left axis, Sβ€² (cm/s) on the right. Dashed lines mark the abnormal cut-offs: TAPSE 17 mm, Sβ€² 9 cm/s and FAC 30% (male) or 35% (female) once sex is selected.

Where LVEF sits

≀35 severely impaired
36–49 impaired
50–54
β‰₯55 normal
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2035505575

BSE LVEF groups: normal β‰₯55%, borderline low 50–54%, impaired 36–49%, severely impaired ≀35%. The CTRCD grade uses the separate ESC 2022 thresholds of 50% and 40%.

Relative GLS change

improved / stable
<8% noise
8–15%
>15% CTRCD
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βˆ’20% better0815+30% worse

A relative fall <8% is unlikely to be meaningful; 8–15% is a grey zone that deserves a repeat; >15% is abnormal (ASE/EACVI; ESC 2022).

Report suggestion

Enter at least a baseline and a current LVEF, then press Analyse.
Click the report to copy it

Export

DICOM saves the LV and RV trends as one greyscale image (Secondary Capture) to upload to your echo or PACS system. PDF saves the scan table and both trends on an A4 page for printing. Both use a white background with line patterns that read in black and white. Files are built in your browser; nothing is sent anywhere.

Echo next steps

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Echo in cardio-oncology

Echo is the first-line test before, during and after cardiotoxic cancer therapy. Every follow-up is judged against the patient's own pre-treatment baseline, so measurement consistency matters as much as the numbers.

GLS

>15%
Relative fall from baseline with LVEF β‰₯50% = mild CTRCD

LVEF fall

β‰₯10 pts
Absolute fall to 40–49% = moderate CTRCD

LVEF

<40%
Any new LVEF below 40% = severe CTRCD

2D LVEF noise

Β±10
Points between scans. Confirm small 2D changes with 3D or contrast

Echo criteria for CTRCD (ESC 2022)

GradeEcho definition
SevereNew LVEF reduction to <40%
ModerateNew LVEF fall by β‰₯10 points to 40–49%, or a fall of <10 points to 40–49% with a relative GLS fall >15%
MildLVEF β‰₯50% with a new relative GLS fall >15%

CTRCD = cancer therapy-related cardiac dysfunction. The full ESC definition also counts a new biomarker rise and grades symptomatic CTRCD clinically; this page uses the imaging criteria only.

How much change is real?

Approximate minimal detectable change between two scans. GLS is more reproducible than 2D LVEF, but only on the same vendor and software.

Changes that do not meet the criteria

  • LVEF fall β‰₯10 points but still β‰₯50%: not CTRCD by definition. Check GLS, confirm with 3D or contrast and shorten the interval.
  • GLS fall 8–15%: grey zone. Repeat on the same vendor; check heart rate, BP and image quality.
  • Abnormal LVEF at baseline: pre-existing LV dysfunction, not CTRCD. Report changes against that baseline.
  • Different vendor for GLS: relative change is not reliable. Re-measure on the baseline vendor if possible.

Every cardio-oncology echo report

  • LVEF with the method stated (3D, 2D biplane, contrast).
  • GLS with vendor/software and the baseline value.
  • Change from baseline: LVEF in points, GLS as a relative %.
  • RV function, diastolic function and LA volume.
  • Pericardium and valves, especially after chest radiotherapy.
  • Heart rate and BP at the time of the scan, and a clear CTRCD statement.

Acquisition

  • Same machine, vendor and software as baseline wherever possible.
  • 3D LVEF first choice; otherwise 2D biplane by the same operator or reader.
  • Contrast if two or more contiguous segments are not seen.
  • GLS from three apical views, 40–90 fps, stable rhythm, no foreshortening.
  • Review the baseline images side by side, not only the numbers.

Pitfalls in serial scans

  • Loading changes during chemotherapy (tachycardia, anaemia, dehydration, fluids) shift LVEF and GLS.
  • Foreshortened apex inflates LVEF and changes GLS.
  • Poor windows after mastectomy, reconstruction, expanders or left chest radiotherapy: use contrast early.
  • Mixing methods (2D, contrast, 3D) between scans: say so in the report.

GLS and cut-offs used by the calculator

GLSInterpretation
More negative than β‰ˆ βˆ’18%Normal for most vendors
βˆ’16% to βˆ’18%Borderline
Less negative than βˆ’16%Likely abnormal
Relative fall <8% / 8–15% / >15%Noise / grey zone / abnormal
MeasureAbnormal
LVEF (BSE)50–54% borderline low, 36–49% impaired, ≀35% severely impaired
TAPSE<17 mm
RV Sβ€²<9 cm/s
RV FAC<30% male, <35% female

Cancer therapies: what to look for and when to scan

A short guide to the main cardiotoxic treatments. Baseline risk (HFA-ICOS) is set by the cardio-oncology team and decides how often to scan.

Anthracyclines (doxorubicin, epirubicin)

Effect: dose-dependent myocyte injury, mostly in the first year; often subclinical first (GLS before LVEF).

  • Baseline TTE for everyone.
  • High risk: TTE every 2 cycles and within 3 months of finishing.
  • Low/medium risk: extra TTE after 250 mg/mΒ² doxorubicin-equivalent.
  • Everyone: TTE 12 months after the last dose.

HER2-targeted (trastuzumab, pertuzumab, T-DM1)

Effect: LV dysfunction that is usually reversible; risk higher after anthracyclines.

  • Baseline TTE, then every 3 months during treatment.
  • TTE 12 months after finishing.
  • Metastatic disease: every 3 months in year 1, then every 6 months if stable.

Immune checkpoint inhibitors

Effect: myocarditis (rare, early, can be fatal), pericarditis, arrhythmia.

  • Baseline TTE for high-risk patients.
  • Urgent TTE if myocarditis is suspected: wall-motion abnormality, GLS fall, wall thickening, effusion. LVEF is often normal early.

VEGF inhibitors (TKIs, bevacizumab)

Effect: hypertension and afterload-driven LV dysfunction.

  • Baseline TTE for high risk; consider for others.
  • High risk: TTE every 3–4 months in year 1, then every 6–12 months.
  • Report BP at the time of the scan.

Other therapies

  • Proteasome inhibitors (carfilzomib): HF and hypertension; baseline TTE.
  • Fluoropyrimidines (5-FU, capecitabine): vasospasm; new regional wall-motion abnormality.
  • Dasatinib: pulmonary hypertension; TR velocity and RV.
  • CAR-T: LV dysfunction with cytokine release syndrome; baseline TTE if heart disease.

Chest radiotherapy and survivors

Effect: late valve disease, pericardial disease, CAD and restrictive physiology, years after treatment.

  • High-risk survivors: TTE at 1, 3 and 5 years, then every 5 years.
  • Mediastinal radiotherapy: screening TTE from 5 years (high risk) or 10 years after, then every 5 years.

References

  1. Lyon AR, LΓ³pez-FernΓ‘ndez T, Couch LS, et al. 2022 ESC Guidelines on cardio-oncology developed in collaboration with EHA, ESTRO and IC-OS. Eur Heart J 2022;43:4229–4361. doi:10.1093/eurheartj/ehac244
  2. Plana JC, Galderisi M, Barac A, et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the ASE and EACVI. J Am Soc Echocardiogr 2014;27:911–939. doi:10.1016/j.echo.2014.07.012
  3. ČelutkienΔ— J, Pudil R, LΓ³pez-FernΓ‘ndez T, et al. Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the HFA, EACVI and the Cardio-Oncology Council of the ESC. Eur J Heart Fail 2020;22:1504–1524. doi:10.1002/ejhf.1957
  4. Dobson R, Ghosh AK, Ky B, et al. BSE and BCOS guideline for transthoracic echocardiographic assessment of adult cancer patients receiving anthracyclines and/or trastuzumab. Echo Res Pract 2021;8:G1–G18. doi:10.1530/ERP-21-0001
  5. Lancellotti P, Nkomo VT, Badano LP, et al. Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: EACVI/ASE. Eur Heart J Cardiovasc Imaging 2013;14:721–740. doi:10.1093/ehjci/jet123
  6. Thavendiranathan P, Negishi T, Somerset E, et al. Strain-guided management of potentially cardiotoxic cancer therapy (SUCCOUR). J Am Coll Cardiol 2021;77:392–401. doi:10.1016/j.jacc.2020.11.020
  7. Lyon AR, Dent S, Stanway S, et al. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies (HFA-ICOS). Eur J Heart Fail 2020;22:1945–1960. doi:10.1002/ejhf.1920
For informative use only. Designed for trained echocardiographers. Summaries are simplified from the cited guidelines and do not replace them or local protocols. Decisions about cancer treatment belong to the oncology and cardio-oncology team.